Solid tumor

Dr. Takuro Kobayashi in Department of Urology, Graduate School of Medicine, Juntendo University, Tokyo has published a paper in "Current issues in molecular biology" titled "T-Cell Receptor Repertoire as a Predictor of Immune-Related Adverse Events in Renal Cell Carcinoma".

Solid tumor

Dr. Masami Yamauchi in Department of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University has published a paper in "COMMUNICATIONS MEDICINE" titled "Lenvatinib activates anti-tumor immunity by suppressing immunoinhibitory infiltrates in the tumor microenvironment of advanced hepatocellular carcinoma".

Dr. Takashi Azuma in Graduate School of Pharmaceutical Sciences, Osaka Medical and Pharmaceutical University Sciences has published a paper in "Science of The Total Environment" titled "Inactivation of antibiotic-resistant bacteria in hospital wastewater by ozone-based advanced water treatment processes".

Basal immunity

Dr. Yukio Nakamura in Repertoire Genesis Inc. have published a paper in "Viruses" titled "Idiotope-Driven T-Cell/B-Cell Collaboration-Based T-Cell Epitope Prediction Using B-Cell Receptor Repertoire Sequences in Infectious Diseases".

In this paper, by combining two theories of immune network theory and Idiotope-driven T-B collaboration and defining the patterns of TCR-recognized epitope motifs(TREMs), we developed a T-cell epitope prediction method that identifies T-cell epitopes derived from antigen proteins by analyzing B-cell receptor (BCR) sequences. This method allowed us to identify T-cell epitopes that contain the same TREM patterns between BCR and viral antigen sequences in two different infectious diseases caused by dengue virus and SARS-CoV-2 infection. The identified epitopes were among the T-cell epitopes detected in previous studies, and T-cell stimulatory immunogenicity was confirmed. Thus, our data support this method as a powerful tool for the discovery of T-cell epitopes from BCR sequences.

Solid tumor

Dr. Yuka Takehara in Department of Radiation Oncology, Fukushima Medical University School of Medicine has published a paper in "Cancer Reports" titled "Anti-PD-1 monoclonal antibody-resistant esophageal squamous cell carcinoma showing the abscopal effect: A case report with T-cell receptor/B-cell receptor repertoire analysis".