Dr. Kisato Nosaka of Kumamoto University Hospital reported the results of BCR repertoire analysis performed using peripheral blood mononuclear cells (PBMC) before mogamulizumab administration in adult T-cell leukemia-lymphoma (ATL) patients. The paper showed that a low proportion of CD2-CD19 + B cells in PBMC was a significant poor prognostic factor for overall survival (OS). In tumor immunity, the immune response of T cells has been attracting attention in advance, but the content newly focuses on the importance of the immune response of B cells.
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