Prof. Kazuhiro Kakimi's research article Increased diversity with reduced "diversity evenness" of tumor infiltrating T-cells for the successful cancer immunotherapy received 2,544 article views in 2018, placing it as one of the top 100 read oncology papers for Scientific Reports in 2018.

This study has shown that to facilitate the optimization of cancer immunotherapy, performed TCR repertoire analysis of tumor-infiltrating CD8+ T-cells in B16 melanoma-bearing mice receiving several immune checkpoint inhibitors.

The paper shows detailed data such as TCR diversity and the number of clones obtained, with and without tumor growth suppression.

Thus, it has been shown that our repertoire analysis can reveal the behavior of T cells in tumors.